Parasitology Division

Major Achievements

  • Life cycle of different parasites viz. Schistosoma nasale, Gastrodiscoides hominis, Gigantocotyle explanatum and Fasciolopsis buski was elucidated.
  • The monumental work on Schistosoma indicum and Orientobilharzia dattai, the blood flukes of domestic animals by Dr. H.D. Srivastava and Dr. S.C. Dutt awarded the prestigious 'Rafi Ahmad Kidwai Memorial Award' in 1964-65.
  • The lung worm vaccine 'Difil' (Dictyocaulus filaria irradiated larva) developed. The vaccine was found helpful in reducing the incidence of lungworms in sheep and goats in the temperate Himalayan region. A Regional Centre of IVRI for mass production of irradiated "Lungworm Vaccine" (first metazoan parasite vaccine) was established at Srinagar in 1973.
  • The infectivity and immunogenicity of T. annulata infected bovine lymphoblastoid cells in in vitro culture were evaluated and complete attenuation was discernible at 50 passage level. The degree of protective immunity was established by laboratory and field trials. The technology of “Live attenuated schizont vaccine of T. annulata” was released by Technology Release Committee (TRC) of IVRI, Izatnagar.
  • The first generation Anti-tick technology has been transferred to Ajay Biotech India Ltd., Pune for its commercialization.
  • Two anti-tick formulations have been developed, characterized and validated under the National Agriculture Science Fund supported programme. Large stage validation is in progress.
  • Microaerophilous stationary phase (MASP) culture technique using Babesia bigemina (Mexican isolate) was successfully adopted and vaccine protocol for laboratory scale was standardized. The immunomodulatory role of Mycobacterium phlei in bovine babesiosis was demonstrated.
  • Diagnostic antigens for early detection of fasciolosis were identified and a dot-ELISA kit having high sensitivity and specificity was developed and evaluated under field conditions.
  • Pure (cloned) line of a north Indian Eimeria tenella isolate has been generated, characterized and is being maintained in the laboratory.
  • Five anti-tick vaccine candidates have been identified by RNAi technology and these are being evaluated as multi antigen vaccine under the experimental challenge condition
  • For monitoring of acaricide resistance in ticks a number of protocols have been established and validated in ten Indian states. Specific mutation in sodium channel and in acetyl cholinesterase 2 genes and over-expression of esterases, monooxygenases and glutathione S-transferases have been implicated as possible resistance mechanism.

This is the official website of ICAR-Indian Veterinary Research Institute (ICAR-IVRI), Izatnagar, an institute under Indian Council of Agricultural Research (ICAR), Deparment of Agricultural Research & Education (DARE), Ministry of Agriculture and Farmers Welfare, Government of India.

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