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Major Activities

The current research activities of the campus is to address issues pertaining to improvement of in-use FMD vaccine:

Major Activities
Bengaluru Campus
  1. A vaccine capable of preventing clinical signs and infection in all susceptible species (sterile immunity).
    • Attenuated candidate vaccines utilizing the concepts of RNA polymerase fidelity and codon pair de-optimization (under DBT-BBSRC project).
  2. A DIVA enabled vaccine with enhanced stability of the capsid protein to elicit a stronger immune response and durable immunity.
    • Empty capsid vaccine: Virus-like particles (VLPs) with improved stability.
  3. Adjuvants to increase duration of immunity of current FMD vaccine:
    • Next Generation adjuvants
    • Molecular adjuvants (ligands of TLR, cytokines, nanoparticles, nano emulsion etc.)
  4. An indirect vaccine potency testing as alternate to live virus challenge studies.
    • An antibody based ELISA format for estimation of whole virus (146S) particle in the vaccine formulation.
    • Development of serology based in vitro assays (SNT and LPB ELISA of post-vaccination serum) as an alternate to in vivo challenge test in cattle.
    • Evaluation of laboratory mice as alternate animal model for potency testing of FMD vaccine.
    • Determination of 146S Content in FMD oil adjuvanted vaccine and correlation with animal protection.
  5. Under Consortium Research Platform (CRP), IVRI Bengaluru is functioning as nodal centre for development of diagnostics and vaccines for major infectious diseases impacting Indian livestock, fisheries and agricultural sectors.
  6. Under Inter-Institutional collaboration, the institute is working on evaluation of selected FMD Virus strains for their potential as vaccine.
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