» Bacteriology & Mycology Division

Major Achievements

Recombinant Cocktail Vaccine
  • A recombinant cocktail vaccine comprising rOmpA and rOmpC provided 83.33% protection against Salmonella challenge.
  • Development of chimeric DNA vaccine construct and recombinant fusion protein as candidate antigens against bovine brucellosis.
  • Recombinant antigen based Latex agglutination test for sero-diagnosis of leptospirosis.
  • About 40 immunoreactive cell-wall associated proteins of Clostridium chauvoei identified.
  • Generation of aroA mutant of Pasteurella multocida P52.
  • Development of genetically modified S19 strain of Brucella abortus as vaccine candidate.
  • A status of freedom from Contagious bovine pleuropneumonia infection in cattle & buffalo was obtained from OIE.
  • A diagnostic kit for Caprine Pleuropneumonia has been developed and found satisfactory for field diagnosis.
  • Diagnostically important protein genes of Leptospira interrogans were produced using recombinant DNA technology and successfully used for serodiagnosis of leptospirosis in animals.
  • Molecular characterization of various mycoplasmal species was carried out for accurate and quick diagnosis of mycoplasma.
  • Direct detection of mycoplasma from tissue materials and nasal strips with the help of PCR was made possible.
  • Whole genome sequencing of Brucella abortus S19Δper.
  • Several Salmonella serovars, namely Billa, Mons, Muenchen, Reinckandorf, Starrenbos, Uganda, Wein, S.I.17:d:1,2,  S.1.17:d (Monophasic) were identified for the first time in India.
  • PCR assays using pncA and oxyR and 500 bp genes for species identification of Mycobacterium tuberculosis and Mycobacterium bovis was standardized.
  • Alternaria sp. and Mortierella wolfii were reported first time in India and the infection due to P. roseus, R. hyalinospora, Gymnoascoides, G. citrinum & Ch. tropicum was established.