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Major Achievements

  • Division has the pride of attaining the First Patent of the Institute in 2007 (A process for preparing a novel herbal formulation for the treatment of mange in animals)
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  • Second patent has been granted for a herbal formulation for the treatment of haemonchosis in animals in July, 2024
  • A patent application has been filed for a process for preparing an indigenous drug formulation for the treatment of diarrhoea in animals.
  • Products such as Mangol, Mange cure, Ringworm cure, Burn cure, Diarrhoea cure, and Anti-haemonchosis formulation have been developed
    • Rinderpest Pillar, IVRI Mukteswar
  • Endogenous ATP was established as a co-transmitter in the rat urinary bladder, and this research culminated into a seminal research paper published in reputed British Journal of Pharmacology
  • Research on Cardiovascular Pharmacology in the Division was complimented in the editorial of Shock Journal
  • Characterization of TRPV4 channels in the endothelium of pulmonary artery led to a seminal publication in the reputed journal, Pharmacological Research
  • Research on Wound healing led to a highly cited paper in International Immunopharmacology with 420 citations within 10 years of its publication
  • Research on hypo-responsiveness to norepinephrine in sepsis (published in Shock Journal) was cited by Nature Medicine journal.
  • Review article from the Division titled “Drug repurposing approach to fight COVID-19” (published in Pharmacological Reports) has a citation of 530 within 5 years of publication.
  • Pravastatin and orlistat attenuated isoprenaline-induced cardiac injury
  • Kaempferol showed vasorelaxation through endothelium-independent pathways in rat isolated pulmonary artery
  • Luteolin alleviated vascular dysfunctions in CLP-induced polymicrobial sepsis in mice
  • Biochanin-A elicited relaxation in coronary artery of goat through different mechanisms and alleviated fibrosis and inflammation in cardiac injury in mice
  • Leptin-induced uterine relaxation was found to be mediated by ObRb receptor, eNOS enzyme and BKCa channels
  • Elevated expression and reduced phosphorylation of uterine RIG-I protein is observed in a murine model of pathogenic preterm labor
  • Leptin decreases the transcription of BKCa channels and Gs to Gi protein-ratio in late pregnant rat uterus
  • Casein kinase 2 inhibition impairs spontaneous and oxytocin-induced contractions in late pregnant mouse uterus
  • Study of lysophosphatidic acid receptors (LPARs) in buffalo uterus demonstrated upregulation of LPAR1 and LPAR6 in early pregnancy
  • Hypercholesterolemia attenuated uterine oxytocin response in mice
  • Weekly administration of betulinic acid prevents development of chronic renal failure from acute renal failure in folic acid-induced mouse model of kidney injury
  • PRE-084, a sigma-1 receptor agonist reduced endoplasmic reticulum stress and profibrotic changes in chronic kidney disease model in rats
  • Betulinic acid and Ursolic acid reduced fibrosis in chronic kidney disease in rats.
  • Chitosan nanoparticles formulation improved MIC in vitro and blood clearance of bacteria of ceftriaxone in septicaemic mice
  • Prenatal exposure to ethion, an organophosphate pesticide caused maternal and fetal toxicity in rats
  • The clinical evaluation of a herbal ointment for healing efficacy was undertaken in natural cases of cutaneous wounds in pigs and it displayed potential to be developed as a technology
  • Icariin improved cutaneous wound healing in normal and diabetic rats due to its angiogenic and MMPs modulatory activity
  • Lecithin-based deferoxamine nanoparticles promoted wound healing in diabetic rats
  • Topical bilirubin-deferoxamine hastened excisional wound healing by modulating inflammation, oxidative stress, angiogenesis, and collagen deposition in diabetic rats
  • Hydroethanolic extract of Limonia acidissima L. unripe fruit pulp powder protects against dextran sulfate sodium-induced ulcerative colitis in mice.
  • Protective effect of Limonia acidissima L. fruit (Wood apple/Kaith bel) sap was observed against capsaicin-induced colonic injury in mice
  • Terminalia chebula fruit extract attenuated inflammation and oxidative stress, improving acute lung injury in a mouse model
  • Combination of candesartan and carvedilol significantly ameliorated the arsenic-induced cardiac toxicity in rats
  • Method standardized for the simultaneous determination of enrofloxacin and oxytetracycline residues in meat samples by UHPLC