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Major Achievement of Lab

  • Ethosome capped C. longa was found to have better wound healing capacity in comparison to crude extract.
  • The MIC of LGE was tested on 67 clinical microbial isolates. The lowest MIC was found as 0.008 µg/ml. against (Bacillus stearothermophilus , Enterobacter agglomerans, Escherichia coli, Staphylococcus lentus and Streptococcus milleri) wheras the highest MIC was recoded as 8 mcg/ml against Alcaligenes faecalis, Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris. Average zone of inhibition recorded against 147 microbial isolates showed concentration dependent increase in ZI viz. 12.5 µg/ml (30.1 mm) and at 25 µg/ml (33.5 mm).
  • The GOE at concentration of 25 µg of GO/ml was found effective against all tested isolates (147 nos) whereas at concentration of 12.5 µg/ml was ineffective against only one isolate of Aspergillus niger out of 147 isolates tested. The GOE tested at 6.25 µg/ml inhibited 139 isolates out of 147 whereas failed to inhibit Bacillus cereus, Paenibacillus alvei (n=2 isolates), Staphylococcus delphini, Aeromonas trota, Aspergillus niger, Enterococcus faecalis and Enterobacter agglomerans.
  • The MIC values remains fairly constant against Staph. aureus (ATCC 29312 and ATCC 43300) and E .coli (NDM)at day 0 and up to 265 day of testing on storage at room temp.
  • MBC values against majority of isolates were in range of 125-250 µg/ml. The lowest value of MBC (3.97 µg/ml) was against Klebsiella 2238HNSP whereas the highest MBC (500 µg/ml) was against E.coli and Streptococcus pyogens isolates.
  • The MFC crude oil was 39 µg/ml against M. canis and T. mentagrophytes whereas the MFC of ethosomal suspensions ethosomes was 78µg/ml and 156 µg/ml respectively against M. canis and T. mentagrophytes.
  • The in vitro release kinetics showed that GOE is sustained released formulation (Zero-order) with perfect fitting with Korsemeyer Peppas and Weibull release models designed for studying the release of drug from polymeric matrix
  • Comparative study of oral and injectible iron therapy with or without ascorbic acid co-administration in piglet anemia demonstrated that both oral and injectible iron indcued severe oxidative stress post treatment. Co-administration of ascobic acid was found effective in alleviating the oxidative stress along with better body weight gain , Hb, N;L ratio and Ig level.
  • Comparative study of nano iron formulation with Asc-INOP and FA- INOP suggested better therapeutic potential of Asc & FA INOPs as compared to bare INOP and conventional ferruos sulphate

List of projects going on in lab

  • Formulation and evaluation of Ethosomes a Novel trans-dermal delivery system for enhanced antimicrobial and antidermatophytic effect of essential oils (ongoing)